Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan
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چکیده
منابع مشابه
Pharmacognostical Evaluation of Caesalpinia sappan Heartwood
Caesalpinia span heartwood is used in folklore in India. The present work attempts to summarize the pharmacognostical characters of the heartwood of this plant. Ash and extractive values, phytochemical tests, HPTLC and fluorescence analysis were carried out. The present work contributes for the standardization of this medicinal heat wood.
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Two new phenolic compounds, caesalpiniaphenols G-H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.7 and 22.5 µg/mL. Treating HL-60 cells with various...
متن کاملEVALUATION OF ANTI-CANCER PROPERTIES OF HEARTWOOD OF Caesalpinia sappan
Objectives: To evaluate the anti-cancer potential of the heartwood of Caesalpinia sappan. Methods: The extraction of the plant material was done using ethyl acetate, methanol and water. Cytotoxicity evaluated using MTT assay. Apoptosis potential was evaluated by cell cycle analysis and Hoechst staining techniques. In vivo anticancer evaluation performed by the Ehrlich’s ascites carcinoma model ...
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Two new phenolic compounds, epicaesalpin J and 7,10,11-trihydroxydracaenone, were isolated from the heartwood of Caesalpinia sappan L. Their structures were identified by spectroscopic analysis methods, such as 1D and 2D NMR, along with the high resolution mass spectral data. The NO inhibition activities of two new compounds and six known compounds were tested.
متن کاملA new 3-benzylchroman derivative from Sappan Lignum (Caesalpinia sappan).
3'-Deoxy-4-O-methylepisappanol, a new 3-benzylchroman derivative, was isolated from Sappan Lignum, together with thirteen known chemical compounds identified as protosappanin A, sappanchalcone, sappanone B, palmitic acid, (+)-(8S,8'S)-bisdihydrosiringenin, brazilein, 3-deoxysappanchalcone, (+)-lyoniresinol, 3-deoxysappanone B, protosappanin B, isoprotosappanin B, 3'-O-methylbrazilin and brazili...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2005
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.53.984